Dewi Driegen was discovered at the age of thirteen by an Elite Model Management Amsterdam modeling scout but decided to stay in school. After her 18th birthday though, she began modeling in Paris and Milan in shows such as Valentino and Versace.

Driegen's first campaign was for the Fall 2002 Balenciaga collection and has continued to do advertisements for Armani Exchange, Gucci, New York & Company, Versus, Barneys and numerous others. She has also appeared on the covers of Russian Vogue in December 2002, UK's Vogue and i-D in March 2003 amongst others. She has also appeared on the Victoria's Secret televised fashion show in 2002 and 2003.

Other runway credits of hers include Alberta Ferretti, Alexander McQueen, Chanel, Christian LaCroix, D&G, Emanuel Ungaro, and Givenchy.